Article
Divergent roles of SHP-2 in ERK activation by leptin receptors.
The Journal of biological chemistry - 16 Feb 2001
Bjørbaek C, Buchholz R M, Davis S M, Bates S H, Pierroz D D, Gu H, Neel B G, Myers M G, Flier J S
Abstract excerpt
The protein tyrosine phosphatase SHP-2 has been proposed to serve as a regulator of leptin signaling, but its specific roles are not fully examined. To directly investigate the role of SHP-2, we employed dominant negative strategies in transfected cells. We show that a catalytically inactive mutant of SHP-2 blocks leptin-stimulated ERK phosphorylation by the long leptin receptor, ObRb. SHP-2, lacking two...
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