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Article

Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism.

Proceedings of the National Academy of Sciences of the United States of America - 9 Nov 2004

Zhang Eric E, Chapeau Emilie, Hagihara Kazuki, Feng Gen-Sheng

Abstract excerpt

Shp2, a Src homology 2-containing tyrosine phosphatase, has been implicated in a variety of growth factor or cytokine signaling pathways. However, it is conceivable that this enzyme acts predominantly in one pathway versus the others in a cell, depending on the cellular context. To determine the putative functions of Shp2 in the adult brain, we selectively deleted Shp2 in postmitotic forebrain neurons by crossing...

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Identifiers

PMID: 15520383
DOI: 10.1073/pnas.0405041101
PMCID: PMC528739

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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