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Article

Crucial Role of the SH2B1 PH Domain for the Control of Energy Balance

22 Aug 2019

Abstract excerpt

Disruption of the adaptor protein SH2B1 (SH2-B, PSM) is associated with severe obesity, insulin resistance, and neurobehavioral abnormalities in mice and humans. Here, we identify 15 SH2B1 variants in severely obese children. Four obesity-associated human SH2B1 variants lie in the Pleckstrin homology (PH) domain, suggesting that the PH domain is essential for SH2B1’s function. We generated a mouse model of a...

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PMID: 31439647
DOI: 10.2337/db19-0608

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