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Article

Substrate-selective and calcium-independent activation of CaMKII by α-actinin.

The Journal of biological chemistry - 4 May 2012

Jalan-Sakrikar Nidhi, Bartlett Ryan K, Baucum Anthony J, Colbran Roger J

Abstract excerpt

Protein-protein interactions are thought to modulate the efficiency and specificity of Ca(2+)/calmodulin (CaM)-dependent protein kinase II (CaMKII) signaling in specific subcellular compartments. Here we show that the F-actin-binding protein α-actinin targets CaMKIIα to F-actin in cells by binding to the CaMKII regulatory domain, mimicking CaM. The interaction with α-actinin is blocked by CaMKII...

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Identifiers

PMID: 22427672
DOI: 10.1074/jbc.M112.351817
PMCID: PMC3346149

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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