Article
CaMKIIα phosphorylation of Shank3 modulates ABI1-Shank3 interaction.
Biochemical and biophysical research communications - 26 Mar 2020
Perfitt Tyler L, Stauffer Philip E, Spiess Keeley L, Colbran Roger J
Abstract excerpt
Protein-protein interactions can be modulated by phosphorylation of either binding partner, thereby altering subcellular localization and/or physiological function. Shank3, a master postsynaptic scaffolding protein that controls the developmental maturation of excitatory synapses, was recently shown to be phosphorylated by Protein Kinase A (PKA) at Ser685 in vivo. Mutation of Shank3 Ser685 was shown to modulate...
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