Article
Regulation of G protein-coupled receptor kinase 5 (GRK5) by actin.
The Journal of biological chemistry - 7 Aug 1998
Freeman J L, De La Cruz E M, Pollard T D, Lefkowitz R J, Pitcher J A
Abstract excerpt
G protein-coupled receptor kinases (GRKs) initiate pathways leading to the desensitization of agonist-occupied G-protein-coupled receptors (GPCRs). Here we report that the cytoskeletal protein actin binds and inhibits GRK5. Actin inhibits the kinase activity directly, reducing GRK5-mediated phosp...
Topics
- Actins
- Amino Acid Sequence
- Calmodulin
- Caseins
- Fluorescence
- G-Protein-Coupled Receptor Kinase 5
- GTP-Binding Proteins
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Protein Binding
- Protein Serine-Threonine Kinases
- Receptor Protein-Tyrosine Kinases
- Rhodopsin
- Substrate Specificity