Article
Excision of Trpv6 gene leads to severe defects in epididymal Ca2+ absorption and male fertility much like single D541A pore mutation.
The Journal of biological chemistry - 25 May 2012
Weissgerber Petra, Kriebs Ulrich, Tsvilovskyy Volodymyr, Olausson Jenny, Kretz Oliver, Stoerger Christof, Mannebach Stefanie, Wissenbach Ulrich, Vennekens Rudi, Middendorff Ralf, Flockerzi Veit, Freichel Marc
Abstract excerpt
Replacement of aspartate residue 541 by alanine (D541A) in the pore of TRPV6 channels in mice disrupts Ca(2+) absorption by the epididymal epithelium, resulting in abnormally high Ca(2+) concentrations in epididymal luminal fluid and in a dramatic but incomplete loss of sperm motility and fertilization capacity, raising the possibility of residual activity of channels formed by TRPV6(D541A) proteins (Weissgerber,...
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