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Article

TRPV4 is the temperature-sensitive ion channel of human sperm

2 Jul 2018

Abstract excerpt

Ion channels control the ability of human sperm to fertilize the egg by triggering hyperactivated motility, which is regulated by membrane potential, intracellular pH, and cytosolic calcium. Previous studies unraveled three essential ion channels that regulate these parameters: (1) the Ca2+ channel CatSper, (2) the K+ channel KSper, and (3) the H+ channel Hv1. However, the molecular identity of the sperm Na+...

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PMID: 29963982
DOI: 10.7554/elife.35853

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