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Article

5-hydroxymethyl-cytosine enrichment of non-committed cells is not a universal feature of vertebrate development

1 Apr 2012

Abstract excerpt

5-hydroxymethyl-cytosine (5-hmC) is a cytosine modification that is relatively abundant in mammalian pre-implantation embryos and embryonic stem cells (ESC) derived from mammalian blastocysts. Recent observations imply that both 5-hmC and Tet1/2/3 proteins, catalyzing the conversion of 5-methyl-cytosine to 5-hmC, may play an important role in self renewal and differentiation of ESCs. Here we assessed the...

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PMID: 22419071
DOI: 10.4161/epi.19375

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