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Article

Aberrant methylation patterns at the two‐cell stage as an indicator of early developmental failure

17 Sept 2002

Abstract excerpt

The fertilized mouse egg actively demethylates the paternal genome within a few hours after fertilization, whereas the maternal genome is only passively demethylated by a replication-dependent mechanism after the two-cell stage. This evolutionarily conserved assymetry in the early diploid mammalian embryo may have a role in methylation reprogramming of the two very different sets of sperm and egg chromatin for...

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PMID: 12237948
DOI: 10.1002/mrd.90016

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