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Article

TDP1-dependent DNA single-strand break repair and neurodegeneration.

Mutagenesis - 1 Jul 2006

El-Khamisy Sherif F, Caldecott Keith W

Abstract excerpt

DNA single-strand breaks (SSBs) are the commonest DNA lesions that arise spontaneously in living cells. Cells employ efficient processes for the rapid repair of these breaks and defects in these processes appear to preferentially impact on the nervous system, causing human ataxia. Spinocerebellar ataxia with axonal neuropathy (SCAN1) is a human disease that is associated with a defect in repairing certain types...

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Identifiers

PMID: 16775218
DOI: 10.1093/mutage/gel024

Genes

TDP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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