Article
DNA single-strand break repair and spinocerebellar ataxia with axonal neuropathy-1.
Neuroscience - 14 Apr 2007
el-Khamisy S F, Caldecott K W
Abstract excerpt
DNA single-strand breaks (SSBs) are the commonest DNA lesions arising spontaneously in cells, and if not repaired may block transcription or may be converted into potentially lethal/clastogenic DNA double-strand breaks (DSBs). Recently, evidence has emerged that defects in the rapid repair of SSBs preferentially impact the nervous system. In particular, spinocerebellar ataxia with axonal neuropathy (SCAN1) is a...
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