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Article

SUMOylation enhances DNA methyltransferase 1 activity.

The Biochemical journal - 15 Jul 2009

Lee Bongyong, Muller Mark T

Abstract excerpt

DNA methylation regulates gene expression through a complex network of protein-protein and protein-DNA interactions in chromatin. The maintenance methylase, DNMT1 (DNA methyltransferase 1), is a prominent enzyme in the process that is linked to DNA replication and drives the heritable nature of epigenetic modifications. The mechanistic details that explain how DNMT1 catalytic action is directed and regulated in...

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Source

Identifiers

PMID: 19450230
DOI: 10.1042/BJ20090142

Genes

DNMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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SUMOylation enhances DNA methyltransferase 1 activity.PMID 19450230Read ↗

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The Role of the DNA Methyltransferase Family and the Therapeutic Potential of DNMT Inhibitors in Tumor TreatmentSemantic proximity Read ↗

Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation.Semantic proximity Read ↗

Characterizing Requirements for Small Ubiquitin-like Modifier (SUMO) Modification and Binding on Base Excision Repair Activity of Thymine-DNA Glycosylase in Vivo.Semantic proximity Read ↗

Mediating and maintaining methylation while minimizing mutation: Recent advances on mammalian DNA methyltransferases.Semantic proximity Read ↗

Mouse embryonic stem cells exhibit cancer-like DNA methylation landscapes upon DNMT1 overexpressionSemantic proximity Read ↗

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Sumoylation in Physiology, Pathology and TherapySemantic proximity Read ↗

Crystal Structure of Human DNA Methyltransferase 1.Semantic proximity Read ↗

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