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Article

Wss1 Promotes Replication Stress Tolerance by Degrading Histones.

Cell reports - 3 Mar 2020

Maddi Karthik, Sam Daniel Kwesi, Bonn Florian, Prgomet Stefan, Tulowetzke Eric, Akutsu Masato, Lopez-Mosqueda Jaime, Dikic Ivan

Abstract excerpt

Timely completion of DNA replication is central to accurate cell division and to the maintenance of genomic stability. However, certain DNA-protein interactions can physically impede DNA replication fork progression. Cells remove or bypass these physical impediments by different mechanisms to preserve DNA macromolecule integrity and genome stability. In Saccharomyces cerevisiae, Wss1, the DNA-protein crosslink...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32130911
DOI: 10.1016/j.celrep.2020.02.018

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