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Article

Functional polymorphisms in the insulin-like binding protein-3 gene may modulate susceptibility to differentiated thyroid carcinoma in Caucasian Americans.

Molecular carcinogenesis - 1 Oct 2012

Xu Li, Mugartegui Liliana, Li Guojun, Sarlis Nicholas J, Wei Qingyi, Zafereo Mark E, Sturgis Erich M

Abstract excerpt

The insulin-like growth factor (IGF) pathway is believed to play a pivotal role in thyroid carcinogenesis. Polymorphisms of IGF-1 and IGF binding protein-3 (IGFBP-3) have been associated with modulation of risk for the emergence of assorted common malignancies, but studies of the influence of such polymorphisms on risk of differentiated thyroid carcinoma (DTC) are lacking. In a case-control study of 173 DTC...

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Identifiers

PMID: 22415807
DOI: 10.1002/mc.21900
PMCID: PMC3473095

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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