Article
Role of polymorphisms of the IGF2 and IGFBP3 genes and risk of gastric carcinoma in China.
Chinese medical journal - 1 Jan 2014
Gu Jun, Li Maolan, Dong Ping, Lu Jianhua, Tan Zhujun, Wu Xiangsong, Mu Jiasheng, Zhang Lin, Wu Wenguang, Ding Qichen, Yang Jiahua, Cao Yang, Ding Qian, Weng Hao, Liu Yingbin
Abstract excerpt
BACKGROUND: The insulin-like growth factor signaling pathway plays an important role in the modulation of cell growth and proliferation. The aim of this study was to investigate the role of polymorphisms of the insulin-like growth factor 2 (IGF2) and IGF-binding protein 3 (IGFBP3) genes, which encode key proteins of this pathway, as risk factors for gastric carcinoma (GC). METHODS: A case-control study including...
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