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Article

Apolipoprotein-E and hepatitis C lipoviral particles in genotype 1 infection: evidence for an association with interferon sensitivity.

Journal of hepatology - 1 Jul 2012

Sheridan David A, Bridge Simon H, Felmlee Daniel J, Crossey Mary M E, Thomas Howard C, Taylor-Robinson Simon D, Toms Geoffrey L, Neely R Dermot G, Bassendine Margaret F

Abstract excerpt

BACKGROUND & AIMS: Hepatitis C virus (HCV) interacts with apolipoproteins B (apoB) and E (apoE) to form infectious lipoviral particles (LVP). Response to peginterferon is influenced by interferon-stimulated genes (ISGs) and IL28B genotype. LDL cholesterol (LDL-C) also predicts interferon response, therefore we hypothesised that LVP may also be associated with interferon sensitivity. METHODS: LVP (HCV RNA density...

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Identifiers

PMID: 22414761
DOI: 10.1016/j.jhep.2012.02.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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