Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Apolipoprotein E-epsilon 4 protects against severe liver disease caused by hepatitis C virus.

Hepatology (Baltimore, Md.) - 1 Aug 2002

Wozniak Matthew A, Itzhaki Ruth F, Faragher E Brian, James Martin W, Ryder Steven D, Irving William L

Abstract excerpt

The outcome of infection with hepatitis C virus (HCV) varies greatly. The virus associates with serum lipoproteins, including those containing apolipoprotein E (apoE) and apolipoprotein B (apoB), and may enter cells via the low-density lipoprotein receptor (LDLR). ApoE genotypes can affect the extent of damage in diseases caused by 2 other viruses--herpes simplex virus type 1 (HSV1; in Alzheimer's disease and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Apolipoprotein E4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoproteins B

Share to Apolipoproteins E

Share to Gene Frequency

Share to Hepatitis C, Chronic

Share to Liver Cirrhosis

Share to Polymorphism, Genetic

Source

Identifiers

PMID: 12143056
DOI: 10.1053/jhep.2002.34745

Genes

LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Apolipoprotein E-epsilon 4 protects against severe liver disease caused by hepatitis C virus.PMID 12143056Read ↗

Apolipoprotein E allele frequencies in chronic and self-limited hepatitis C suggest a protective effect of APOE4 in the course of hepatitis C virus infection.Semantic proximity Read ↗

Apolipoprotein E genotype and hepatitis C, HIV and herpes simplex disease risk: a literature review.Semantic proximity Read ↗

Impact of IL10, MTP, SOD2, and APOE Gene Polymorphisms on the Severity of Liver Fibrosis Induced by HCV Genotype 4.Semantic proximity Read ↗

Human leukocyte antigen class II alleles may contribute to the severity of hepatitis C virus-related liver disease.Semantic proximity Read ↗

Apolipoprotein-E and hepatitis C lipoviral particles in genotype 1 infection: evidence for an association with interferon sensitivity.Semantic proximity Read ↗

Apolipoprotein epsilon3 allele is associated with persistent hepatitis C virus infection.Semantic proximity Read ↗

Impact of apolipoprotein E genetic polymorphisms on liver disease: An essential reviewSemantic proximity Read ↗

Association between apolipoprotein E genotype, chronic liver disease, and hepatitis B virus.Semantic proximity Read ↗

Carriage of the apolipoprotein E-epsilon4 allele and histologic outcome of recurrent hepatitis C after antiviral treatment.Semantic proximity Read ↗

Roles of human apolipoprotein E in the infectivity and replication of hepatitis C virus genotype 2a.Semantic proximity Read ↗

Apolipoprotein E-ε4 deficiency and cognitive function in hepatitis C virus-infected patients.Semantic proximity Read ↗

Syndecan 4 Is Involved in Mediating HCV Entry through Interaction with Lipoviral Particle-Associated Apolipoprotein ESemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.