Article
Genotype rs8099917 near the IL28B gene and amino acid substitution at position 70 in the core region of the hepatitis C virus are determinants of serum apolipoprotein B-100 concentration in chronic hepatitis C.
Molecular and cellular biochemistry - 1 Jan 2012
Aizawa Yoshio, Yohizawa Kai, Aida Yuta, Ishiguro Haruya, Abe Hiroshi, Tsubota Akihito
Abstract excerpt
The life cycle of the hepatitis C virus (HCV) is closely related to host lipoprotein metabolism. Serum levels of lipid are associated with the response to pegylated interferon plus ribavirin (PEG-IFN/RBV) therapy, while single nucleotide polymorphisms (SNPs) around the human interleukin 28B (IL28B) gene locus and amino acid substitutions in the core region of the HCV have been reported to affect the efficacy of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.