Apolipoprotein E allele frequencies in chronic and self-limited hepatitis C suggest a protective effect of APOE4 in the course of hepatitis C virus infection.

doi:10.1111/liv.13094

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Article

Apolipoprotein E allele frequencies in chronic and self-limited hepatitis C suggest a protective effect of APOE4 in the course of hepatitis C virus infection.

Liver international : official journal of the International Association for the Study of the Liver - 1 Sept 2016

Mueller Tobias, Fischer Janett, Gessner Reinhard, Rosendahl Jonas, Böhm Stephan, van Bömmel Florian, Knop Viola, Sarrazin Christoph, Witt Heiko, Marques Andreas Mas, Kovacs Peter, Schleinitz Dorit, Stumvoll Michael, Blüher Matthias, Bugert Peter, Schott Eckart, Berg Thomas

Abstract excerpt

BACKGROUND & AIMS: Infectious hepatitis C virus (HCV) particles bind to host lipoproteins such as low-density lipoproteins (LDLs). Low-density lipoprotein receptors (LDLR) have been termed candidate receptors for HCV-LDL complexes. Functional host genetic single nucleotide polymorphisms (SNPs) in the apolipoprotein E (APOE) gene encoding apolipoprotein E (apoE) - a major structural LDL component and natural...

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PMID: 26880346
DOI: 10.1111/liv.13094

Genes

APOE
LDLR

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