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Article

PCSK9, apolipoprotein E and lipoviral particles in chronic hepatitis C genotype 3: evidence for genotype-specific regulation of lipoprotein metabolism.

Journal of hepatology - 1 Apr 2015

Bridge Simon H, Sheridan David A, Felmlee Daniel J, Crossey Mary M E, Fenwick Fiona I, Lanyon Clare V, Dubuc Geneviève, Seidah Nabil G, Davignon Jean, Thomas Howard C, Taylor-Robinson Simon D, Toms Geoffrey L, Neely R Dermot G, Bassendine Margaret F

Abstract excerpt

BACKGROUND & AIMS: Hepatitis C virus (HCV) associates with lipoproteins to form "lipoviral particles" (LVPs) that can facilitate viral entry into hepatocytes. Initial attachment occurs via heparan sulphate proteoglycans and low-density lipoprotein receptor (LDLR); CD81 then mediates a post-attachment event. Proprotein convertase subtilisin kexin type 9 (PCSK9) enhances the degradation of the LDLR and modulates...

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Share to Cholesterol, LDL
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25463543
DOI: 10.1016/j.jhep.2014.11.016

Genes

PCSK9
LDLR

Provenance

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