Hepatitis C virus infection alters lipid metabolism depending on IL28B polymorphism and viral genotype and modulates gene expression in vivo and in vitro.

doi:10.1111/jvh.12209

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Article

Hepatitis C virus infection alters lipid metabolism depending on IL28B polymorphism and viral genotype and modulates gene expression in vivo and in vitro.

Journal of viral hepatitis - 1 Jan 2014

Rojas Á, del Campo J A, Maraver M, Aparcero R, García-Valdecasas M, Diago M, Carmona I, Andrade R J, Solà R, Romero-Gómez M

Abstract excerpt

Hepatitis C virus (HCV) interacts with lipid receptors to enter the cell, circulates as lipoviroparticle and is secreted as VLDL. We aimed to investigate the role of the rs12979860 polymorphism in the IL28B gene in 143 with chronic hepatitis C genotype 1, 144 infected with genotype 3, 90 genotype 4 and 413 noninfected individuals on lipid profile and to test the impact of HCV infection in an in vitro model on...

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Identifiers

PMID: 24188401
DOI: 10.1111/jvh.12209

Genes

DGAT1
DGAT2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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