Article
Maximum levels of hepatitis C virus lipoviral particles are associated with early and persistent infection.
Liver international : official journal of the International Association for the Study of the Liver - 1 Dec 2016
Sheridan David A, Hajarizadeh Behzad, Fenwick Fiona I, Matthews Gail V, Applegate Tanya, Douglas Mark, Neely Dermot, Askew Bev, Dore Gregory J, Lloyd Andrew R, George Jacob, Bassendine Margaret F, Grebely Jason
Abstract excerpt
BACKGROUND & AIMS: Hepatitis C virus (HCV) is bound to plasma lipoproteins and circulates as an infectious lipoviral particle (LVP). Experimental evidence indicates that LVPs have decreased susceptibility to antibody-mediated neutralisation and higher infectivity. This study tested the hypothesis that LVPs are required to establish persistent infection, and conversely, low levels of LVP in recent HCV infection...
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