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Article

KCC2 transport activity requires the highly conserved L₆₇₅ in the C-terminal β1 strand.

Biochemical and biophysical research communications - 13 Apr 2012

Döding Annika, Hartmann Anna-Maria, Beyer Timo, Nothwang Hans Gerd

Abstract excerpt

The activity of the neuron-specific K(+), Cl(-) co-transporter 2 (KCC2) is required for hyperpolarizing action of GABA and glycine. KCC2-mediated transport therefore plays a pivotal role in neuronal inhibition. Few analyses have addressed the amino acid requirements for transport-competent conformation. KCC2 consists of 12 transmembrane domains flanked by two intracellular termini. Structural analyses of a...

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PMID: 22414695
DOI: 10.1016/j.bbrc.2012.02.147

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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