Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dependence of KCC2 K-Cl cotransporter activity on a conserved carboxy terminus tyrosine residue.

American journal of physiology. Cell physiology - 1 Sept 2000

Strange K, Singer T D, Morrison R, Delpire E

Abstract excerpt

K-Cl cotransporters (KCC) play fundamental roles in ionic and osmotic homeostasis. To date, four mammalian KCC genes have been identified. KCC2 is expressed exclusively in neurons. Injection of Xenopus oocytes with KCC2 cRNA induced a 20-fold increase in Cl(-)-dependent, furosemide-sensitive K(+) uptake. Oocyte swelling increased KCC2 activity 2-3 fold. A canonical tyrosine phosphorylation site is located in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carrier Proteins
Share to Conserved Sequence
Share to Molecular Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oocytes

Share to Rabbits

Share to Symporters

Share to Tyrosine

Share to Xenopus laevis

Source

Identifiers

PMID: 10942735
DOI: 10.1152/ajpcell.2000.279.3.C860

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dependence of KCC2 K-Cl cotransporter activity on a conserved carboxy terminus tyrosine residue.PMID 10942735Read ↗

A novel regulatory locus of phosphorylation in the C terminus of the potassium chloride cotransporter KCC2 that interferes with N-ethylmaleimide or staurosporine-mediated activation.Semantic proximity Read ↗

A C-terminal domain in KCC2 confers constitutive K+-Cl- cotransport.Semantic proximity Read ↗

The potassium chloride cotransporter KCC-2 coordinates development of inhibitory neurotransmission and synapse structure in Caenorhabditis elegans.Semantic proximity Read ↗

A Novel View on the Role of Intracellular Tails in Surface Delivery of the Potassium-Chloride Cotransporter KCC2.Semantic proximity Read ↗

KCC2 transport activity requires the highly conserved L₆₇₅ in the C-terminal β1 strand.Semantic proximity Read ↗

C-terminal determinants of Kir4.2 channel expression.Semantic proximity Read ↗

<i>Nckx30c</i> , a <i>Drosophila</i> K <sup>+</sup> -dependent Na <sup>+</sup> /Ca <sup>2+</sup> exchanger, regulates temperature-sensitive convulsions and age-related neurodegenerationSemantic proximity Read ↗

Nckx30c, a Drosophila K+-dependent Na+/Ca2+ exchanger, regulates temperature-sensitive convulsions and age-related neurodegeneration.Semantic proximity Read ↗

Phosphoregulation of the intracellular termini of K+-Cl- cotransporter 2 (KCC2) enables flexible control of its activity.Semantic proximity Read ↗

A small conductance calcium-activated K+ channel in C. elegans, KCNL-2, plays a role in the regulation of the rate of egg-laying.Semantic proximity Read ↗

C-terminal domain of Kv4.2 and associated KChIP2 interactions regulate functional expression and gating of Kv4.2.Semantic proximity Read ↗

Phosphoregulation of the Na-K-2Cl and K-Cl cotransporters by the WNK kinases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.