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Article

Regulated degradation of KCC2, a potassium-chloride co-transporter required for synaptic transmission and neurodevelopment.

Channels (Austin, Tex.) - 1 Dec 2026

Kok Morgan, Aizenman Elias, Guerriero Christopher J, Brodsky Jeffrey L

Abstract excerpt

Neuronal function requires fine-tuned and coordinated activity of several ion channels and transporters. One member of this ensemble is the KCC2 potassium-chloride cotransporter. Because KCC2 expression is required for GABA-dependent inhibitory synaptic transmission, mutations in the gene encoding KCC2 (SLC12A5) have been linked to several diseases that also arise from defects in GABA signaling, including...

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Identifiers

PMID: 41433127
DOI: 10.1080/19336950.2025.2607247
PMCID: PMC12758278

Genes

SLC12A5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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