Article
A C-terminal domain in KCC2 confers constitutive K+-Cl- cotransport.
The Journal of biological chemistry - 13 Jan 2006
Mercado Adriana, Broumand Vadjista, Zandi-Nejad Kambiz, Enck Alissa H, Mount David B
Abstract excerpt
The neuron-specific K(+)-Cl(-) cotransporter KCC2 plays a crucial role in determining intracellular chloride activity and thus the neuronal response to gamma-aminobutyric acid and glycine. Of the four KCCs, KCC2 is unique in mediating constitutive K(+)-Cl(-) cotransport under isotonic conditions; the other three KCCs are exclusively swelling-activated, with no isotonic activity. We have utilized a series of...
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