Conformational changes required for H(+)/Cl(-) exchange mediated by a CLC transporter.

doi:10.1038/nsmb.2814

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Article

Conformational changes required for H(+)/Cl(-) exchange mediated by a CLC transporter.

Nature structural & molecular biology - 1 May 2014

Basilio Daniel, Noack Kristin, Picollo Alessandra, Accardi Alessio

Abstract excerpt

CLC-type exchangers mediate transmembrane Cl(-) transport. Mutations altering their gating properties cause numerous genetic disorders. However, their transport mechanism remains poorly understood. In conventional models, two gates alternatively expose substrates to the intra- or extracellular solutions. A glutamate was identified as the only gate in the CLCs, suggesting that CLCs function by a nonconventional...

Topics

Biological Transport
Chloride Channels
Crystallography, X-Ray
Escherichia coli K12
Escherichia coli Proteins
Models, Molecular
Mutation
Protein Structure, Tertiary

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PMID: 24747941
DOI: 10.1038/nsmb.2814
PMCID: PMC4040230

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