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Article

Could tuning of the inhibitory tone involve graded changes in neuronal chloride transport?

Neuropharmacology - 1 Aug 2015

Titz Stefan, Sammler Esther M, Hormuzdi Sheriar G

Abstract excerpt

Hyperpolarizing synaptic inhibition through GABAA and glycine receptors depends on the presence of the neuronal cation-chloride-cotransporter protein, KCC2. Several transcriptional and post-transcriptional mechanisms have been shown to regulate KCC2 and thereby influence the polarity and efficacy of inhibitory synaptic transmission. It is unclear however whether regulation of KCC2 enables the transporter to...

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PMID: 25843644
DOI: 10.1016/j.neuropharm.2015.03.026

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