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Article

Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations.

The Journal of general physiology - 1 Apr 2012

Cui Yuanyuan, Yang Fan, Cao Xu, Yarov-Yarovoy Vladimir, Wang KeWei, Zheng Jie

Abstract excerpt

The capsaicin receptor transient receptor potential vanilloid (TRPV)1 is a highly heat-sensitive ion channel. Although chemical activation and heat activation of TRPV1 elicit similar pungent, painful sensation, the molecular mechanism underlying synergistic activation remains mysterious. In particular, where the temperature sensor is located and whether heat and capsaicin share a common activation pathway are...

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Source

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Identifiers

PMID: 22412190
DOI: 10.1085/jgp.201110724
PMCID: PMC3315147

Genes

TRPV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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