Article
Pore region of TRPV3 ion channel is specifically required for heat activation.
Nature neuroscience - 1 Sept 2008
Grandl Jörg, Hu Hongzhen, Bandell Michael, Bursulaya Badry, Schmidt Manuela, Petrus Matt, Patapoutian Ardem
Abstract excerpt
Ion channels can be activated (gated) by a variety of stimuli, including chemicals, voltage, mechanical force or temperature. Although molecular mechanisms of ion channel gating by chemical and voltage stimuli are understood in principal, the mechanisms of temperature activation remain unknown. The transient receptor potential channel TRPV3 is a nonselective cation channel that is activated by warm temperatures...
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