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Article

Protons stabilize the closed conformation of gain-of-function mutants of the TRPV1 channel.

Biochimica et biophysica acta - 1 Mar 2013

Boukalova Stepana, Teisinger Jan, Vlachova Viktorie

Abstract excerpt

The vanilloid transient receptor potential channel TRPV1 is a molecular integrator of noxious stimuli, including capsaicin, heat and protons. Despite clear similarities between the overall architecture of TRPV1 and voltage-dependent potassium (Kv) channels, the extent of conservation in the molecular logic for gating is unknown. In Kv channels, a small contact surface between S1 and the pore-helix is required for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23220012
DOI: 10.1016/j.bbamcr.2012.11.017

Genes

TRPV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Protons stabilize the closed conformation of gain-of-function mutants of the TRPV1 channel.PMID 23220012Read ↗

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