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Article

Myeloid leukemia factor is a conserved regulator of RUNX transcription factor activity involved in hematopoiesis.

Proceedings of the National Academy of Sciences of the United States of America - 27 Mar 2012

Bras Stéphanie, Martin-Lannerée Séverine, Gobert Vanessa, Augé Benoît, Breig Osman, Sanial Matthieu, Yamaguchi Masamitsu, Haenlin Marc, Plessis Anne, Waltzer Lucas

Abstract excerpt

Defining the function of the genes that, like RUNX1, are deregulated in blood cell malignancies represents an important challenge. Myeloid leukemia factors (MLFs) constitute a poorly characterized family of conserved proteins whose founding member, MLF1, has been associated with acute myeloid leukemia in humans. To gain insight into the functions of this family, we investigated the role of the Drosophila MLF...

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Share to Cell Lineage
Share to Core Binding Factor Alpha 2 Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryo, Nonmammalian

Share to Hematopoiesis

Share to Oncogene Proteins, Fusion

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Source

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Identifiers

PMID: 22411814
DOI: 10.1073/pnas.1117317109
PMCID: PMC3324030

Genes

RUNX1
MLF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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