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Article

Differences in expression and function of LEF1 isoforms in normal versus leukemic hematopoiesis.

Leukemia - 1 Apr 2020

Feder Kristin, Edmaier-Schröger Katrin, Rawat Vijay P S, Kirsten Nicole, Metzeler Klaus, Kraus Johann M, Döhner Konstanze, Döhner Hartmut, Kestler Hans A, Feuring-Buske Michaela, Buske Christian

Abstract excerpt

Acute myeloid leukemia (AML) is the most common acute leukemia in adults and is propagated by leukemic stem cells (LSCs), often characterized by deregulated Wnt signaling. We previously showed that the central transcriptional mediator of Wnt signaling LEF1 is able to cause AML in mice and acts as an independent prognostic factor in normal karyotype AML. Here, we show that treatment naïve normal karyotype AML as...

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PMID: 31758089
DOI: 10.1038/s41375-019-0635-1

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