Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells

26 Aug 2013

Abstract excerpt

RUNX1 is generally considered a tumor suppressor in myeloid neoplasms. Inactivating RUNX1 mutations have frequently been found in patients with myelodysplastic syndrome (MDS) and cytogenetically normal acute myeloid leukemia (AML). However, no somatic RUNX1 alteration was found in AMLs with leukemogenic fusion proteins, such as core-binding factor (CBF) leukemia and MLL fusion leukemia, raising the possibility...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Histone Deacetylase Inhibitors Research
Share to Protein Degradation and Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23979164
DOI: 10.1172/jci68557

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcription factor RUNX1 promotes survival of acute myeloid leukemia cellsPMID 23979164Read ↗

Role of RUNX1 in hematological malignanciesSemantic proximity Read ↗

Normal and transforming functions of RUNX1: A perspectiveSemantic proximity Read ↗

RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesisSemantic proximity Read ↗

Role of AML1/Runx1 in the pathogenesis of hematological malignanciesSemantic proximity Read ↗

RUNX1 and cancerSemantic proximity Read ↗

RUNX1 mutations promote leukemogenesis of myeloid malignancies in ASXL1-mutated leukemia.Semantic proximity Read ↗

Distinct association of RUNX family expression with genetic alterations and clinical outcome in acute myeloid leukemia.Semantic proximity Read ↗

RUNX1 mutations in cytogenetically normal acute myeloid leukemia are associated with a poor prognosis and up-regulation of lymphoid genes.Semantic proximity Read ↗

Targeting RUNX1 in acute myeloid leukemia: preclinical innovations and therapeutic implications.Semantic proximity Read ↗

Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal.Semantic proximity Read ↗

Increased expression of RUNX3 inhibits normal human myeloid developmentSemantic proximity Read ↗

Runx transcription factors in the development and function of the definitive hematopoietic system.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.