Article
Neurexin dysfunction in adult neurons results in autistic-like behavior in mice.
Cell reports - 24 Jul 2014
Rabaneda Luis G, Robles-Lanuza Estefanía, Nieto-González José Luis, Scholl Francisco G
Abstract excerpt
Autism spectrum disorders (ASDs) comprise a group of clinical phenotypes characterized by repetitive behavior and social and communication deficits. Autism is generally viewed as a neurodevelopmental disorder where insults during embryonic or early postnatal periods result in aberrant wiring and function of neuronal circuits. Neurexins are synaptic proteins associated with autism. Here, we generated transgenic...
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