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Article

Differential involvement of the extracellular 6-O-endosulfatases Sulf1 and Sulf2 in brain development and neuronal and behavioural plasticity.

Journal of cellular and molecular medicine - 1 Jan 2000

Kalus Ina, Salmen Benedikt, Viebahn Christoph, von Figura Kurt, Schmitz Dietmar, D'Hooge Rudi, Dierks Thomas

Abstract excerpt

The extracellular sulfatases Sulf1 and Sulf2 remove specific 6-O-sulfate groups from heparan sulfate, thereby modulating numerous signalling pathways underlying development and homeostasis. In vitro data have suggested that the two enzymes show functional redundancy. To elucidate their in vivo functions and to further address the question of a putative redundancy, we have generated Sulf1- and Sulf2-deficient...

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Identifiers

PMID: 20394677
DOI: 10.1111/j.1582-4934.2008.00558.x
PMCID: PMC4515066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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