Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Defective heparan sulfate biosynthesis and neonatal lethality in mice lacking N-deacetylase/N-sulfotransferase-1.

The Journal of biological chemistry - 25 Aug 2000

Ringvall M, Ledin J, Holmborn K, van Kuppevelt T, Ellin F, Eriksson I, Olofsson A M, Kjellen L, Forsberg E

Abstract excerpt

Heparan sulfate is a sulfated polysaccharide present on most cell surfaces and in the extracellular matrix. In vivo functions of heparan sulfate can be studied in mouse strains lacking enzymes involved in the biosynthesis of heparan sulfate. Glucosaminyl N-deacetylase/N-sulfotransferase (NDST) ca...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amidohydrolases
Share to Fibroblasts
Share to Heparitin Sulfate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Phenotype

Share to Sulfotransferases

Source

Identifiers

PMID: 10852901
DOI: 10.1074/jbc.C000359200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10852901-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Defective heparan sulfate biosynthesis and neonatal lethality in mice lacking N-deacetylase/N-sulfotransferase-1.PMID 10852901Read ↗

Enzymatically active N-deacetylase/N-sulfotransferase-2 is present in liver but does not contribute to heparan sulfate N-sulfation.Semantic proximity Read ↗

Cerebral hypoplasia and craniofacial defects in mice lacking heparan sulfate Ndst1 gene function.Semantic proximity Read ↗

Heparan sulfate structure in mice with genetically modified heparan sulfate production.Semantic proximity Read ↗

Systemic inactivation of Hs6st1 in mice is associated with late postnatal mortality without major defects in organogenesis.Semantic proximity Read ↗

Heparan sulfate synthesized by mouse embryonic stem cells deficient in NDST1 and NDST2 is 6-O-sulfated but contains no N-sulfate groups.Semantic proximity Read ↗

Role of heparan sulfate-2-O-sulfotransferase in the mouse.Semantic proximity Read ↗

Altered heparan sulfate structure in mice with deleted NDST3 gene function.Semantic proximity Read ↗

Heparan sulfate: lessons from knockout mice.Semantic proximity Read ↗

Targeted disruption of a murine glucuronyl C5-epimerase gene results in heparan sulfate lacking L-iduronic acid and in neonatal lethality.Semantic proximity Read ↗

Heparan Sulfate Biosynthesis in Zebrafish.Semantic proximity Read ↗

Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development.Semantic proximity Read ↗

Chondroitin/dermatan sulfate glycosyltransferase genes are essential for craniofacial development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.