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Article

Mammalian brain morphogenesis and midline axon guidance require heparan sulfate.

Science (New York, N.Y.) - 7 Nov 2003

Inatani Masaru, Irie Fumitoshi, Plump Andrew S, Tessier-Lavigne Marc, Yamaguchi Yu

Abstract excerpt

Heparan sulfate (HS) is required for morphogen signaling during Drosophila pattern formation, but little is known about its physiological importance in mammalian development. To define the developmental role of HS in mammalian species, we conditionally disrupted the HS-polymerizing enzyme EXT1 in the embryonic mouse brain. The EXT1-null brain exhibited patterning defects that are composites of those caused by...

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Identifiers

PMID: 14605369
DOI: 10.1126/science.1090497

Genes

EXT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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