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Article

Gangliosides and chondroitin sulfate desensitize and internalize B2 bradykinin receptors.

Biochemical and biophysical research communications - 30 Mar 2012

Shimazaki Ayaka, Nakagawa Tetsuto, Mitoma Junya, Higashi Hideyoshi

Abstract excerpt

Prolonged or repeated agonist activation of G-protein-coupled receptors (GPCRs) initiates their desensitization and internalization, rendering them unresponsive to agonist activation. We analyzed how gangliosides and chondroitin sulfate affect B2 bradykinin (BK) receptors (B2Rs). Gangliosides and...

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PMID: 22409970
DOI: 10.1016/j.bbrc.2012.02.142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22409970-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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