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Article

Distinct domains of the CB1 cannabinoid receptor mediate desensitization and internalization.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 May 1999

Jin W, Brown S, Roche J P, Hsieh C, Celver J P, Kovoor A, Chavkin C, Mackie K

Abstract excerpt

Desensitization of cannabinoid receptor signaling by a G-protein coupled receptor kinase (GRK) was examined using the Xenopus oocyte expression system. Application of a CB1 agonist, WIN 55,212-2, evoked a concentration-dependent increase in K+ conductance (Kir3) in oocytes coexpressing rat CB1 with the G-protein-gated, inwardly rectifying K+ channels Kir3.1 and Kir3.4. Desensitization was slight during continuous...

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Identifiers

PMID: 10234009
PMCID: PMC6782730

Genes

GRK3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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