Article
Internalization-defective mutants of somatostatin receptor subtype 2 exert normal signaling functions in hematopoietic cells.
FEBS letters - 17 Aug 2001
Oomen S P, Hofland L J, Lamberts S W, Löwenberg B, Touw I P
Abstract excerpt
The regulatory peptide somatostatin (SST) acts via a family of G-protein-coupled receptors comprising five subtypes (SSTR1-5). G-protein-coupled receptors activate multiple signaling mechanisms, which variably depend on internalization and intracellular routing of activated receptors. We have recently demonstrated that hematopoietic precursors express SSTR2 and that SST is a chemoattractant for these cells....
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