Article
Function of GB1 and GB2 subunits in G protein coupling of GABA(B) receptors.
Proceedings of the National Academy of Sciences of the United States of America - 4 Dec 2001
Margeta-Mitrovic M, Jan Y N, Jan L Y
Abstract excerpt
Many G protein-coupled receptors (GPCRs) have recently been shown to dimerize, and it was suggested that dimerization may be a prerequisite for G protein coupling. gamma-aminobutyric acid type B (GABA(B)) receptors (GPCRs for GABA, a major inhibitory neurotransmitter in the brain) are obligate heterodimers of homologous GB1 and GB2 subunits, neither of which is functional on its own. This feature of GABA(B)...
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