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Article

CEF1/CDC5 alleles modulate transitions between catalytic conformations of the spliceosome.

RNA (New York, N.Y.) - 1 May 2012

Query Charles C, Konarska Maria M

Abstract excerpt

Conformational change within the spliceosome is required between the first and second catalytic steps of pre-mRNA splicing. A prior genetic screen for suppressors of an intron mutant that stalls between the two steps yielded both prp8 and non-prp8 alleles that suppressed second-step splicing defects. We have now identified the strongest non-prp8 suppressors as alleles of the NTC (Prp19 complex) component, CEF1....

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Identifiers

PMID: 22408182
DOI: 10.1261/rna.029421.111
PMCID: PMC3334688

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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