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Article

Opposing classes of prp8 alleles modulate the transition between the catalytic steps of pre-mRNA splicing.

Nature structural & molecular biology - 1 Jun 2007

Liu Li, Query Charles C, Konarska Maria M

Abstract excerpt

The spliceosome is thought to undergo a conformational change between the two catalytic steps of precursor messenger RNA splicing, although the specific events in this transition are poorly understood. We previously proposed a two-state model of splicing in which the conformations required for the first and second steps are in competition. Here, we identify and characterize a class of prp8 mutants that suppress...

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PMID: 17486100
DOI: 10.1038/nsmb1240

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Opposing classes of prp8 alleles modulate the transition between the catalytic steps of pre-mRNA splicing.PMID 17486100Read ↗

Suppression of multiple substrate mutations by spliceosomal prp8 alleles suggests functional correlations with ribosomal ambiguity mutants.Semantic proximity Read ↗

Distinct domains of splicing factor Prp8 mediate different aspects of spliceosome activation.Semantic proximity Read ↗

Characterization of Cwc2, U6 snRNA, and Prp8 interactions destabilized by Prp16 ATPase at the transition between the first and second steps of splicing.Semantic proximity Read ↗

Allele-specific genetic interactions between Prp8 and RNA active site residues suggest a function for Prp8 at the catalytic core of the spliceosome.Semantic proximity Read ↗

Activation of Prp28 ATPase by phosphorylated Npl3 at a critical step of spliceosome remodeling.Semantic proximity Read ↗

An RNA switch at the 5' splice site requires ATP and the DEAD box protein Prp28p.Semantic proximity Read ↗

CEF1/CDC5 alleles modulate transitions between catalytic conformations of the spliceosome.Semantic proximity Read ↗

Splicing proofreading at 5' splice sites by ATPase Prp28p.Semantic proximity Read ↗

The DExD/H-box ATPase Prp2p destabilizes and proofreads the catalytic RNA core of the spliceosome.Semantic proximity Read ↗

Structural toggle in the RNaseH domain of Prp8 helps balance splicing fidelity and catalytic efficiency.Semantic proximity Read ↗

Genetic interactions between the yeast RNA helicase homolog Prp16 and spliceosomal snRNAs identify candidate ligands for the Prp16 RNA-dependent ATPase.Semantic proximity Read ↗

Structural elucidation of a PRP8 core domain from the heart of the spliceosome.Semantic proximity Read ↗

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