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Article

Prp45 affects Prp22 partition in spliceosomal complexes and splicing efficiency of non-consensus substrates.

Journal of cellular biochemistry - 1 Jan 2009

Gahura Ondrej, Abrhámová Katerina, Skruzný Michal, Valentová Anna, Munzarová Vanda, Folk Petr, Půta Frantisek

Abstract excerpt

Human transcription co-regulator SNW1/SKIP is implicated in the regulation of both transcription elongation and alternative splicing. Prp45, the SNW/SKIP ortholog in yeast, is assumed to be essential for pre-mRNA processing. Here, we characterize prp45(1-169), a temperature sensitive allele of PRP45, which at permissive temperature elicits cell division defects and hypersensitivity to microtubule inhibitors....

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Source

Identifiers

PMID: 19016306
DOI: 10.1002/jcb.21989

Genes

SLU7
SNW1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Prp45 affects Prp22 partition in spliceosomal complexes and splicing efficiency of non-consensus substrates.PMID 19016306Read ↗

Truncating the spliceosomal 'rope protein' Prp45 results in Htz1 dependent phenotypes.Semantic proximity Read ↗

A cold-sensitive mRNA splicing mutant is a member of the RNA helicase gene family.Semantic proximity Read ↗

Extensive genetic interactions between PRP8 and PRP17/CDC40, two yeast genes involved in pre-mRNA splicing and cell cycle progression.Semantic proximity Read ↗

A targeted bypass screen identifies Ynl187p, Prp42p, Snu71p, and Cbp80p for stable U1 snRNP/Pre-mRNA interaction.Semantic proximity Read ↗

The Prp19C subunits Cwc15 and Syf2 function in TREX occupancy and transcription elongationSemantic proximity Read ↗

How Slu7 and Prp18 cooperate in the second step of yeast pre-mRNA splicing.Semantic proximity Read ↗

CEF1/CDC5 alleles modulate transitions between catalytic conformations of the spliceosome.Semantic proximity Read ↗

Suppressors of a cold-sensitive mutation in yeast U4 RNA define five domains in the splicing factor Prp8 that influence spliceosome activation.Semantic proximity Read ↗

Snt309p, a component of the Prp19p-associated complex that interacts with Prp19p and associates with the spliceosome simultaneously with or immediately after dissociation of U4 in the same manner as Prp19p.Semantic proximity Read ↗

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