Article
A genetic screen in C. elegans reveals roles for KIN17 and PRCC in maintaining 5' splice site identity.
PLoS genetics - 1 Feb 2022
Suzuki Jessie M N G L, Osterhoudt Kenneth, Cartwright-Acar Catiana H, Gomez Destiny R, Katzman Sol, Zahler Alan M
Abstract excerpt
Pre-mRNA splicing is an essential step of eukaryotic gene expression carried out by a series of dynamic macromolecular protein/RNA complexes, known collectively and individually as the spliceosome. This series of spliceosomal complexes define, assemble on, and catalyze the removal of introns. Molecular model snapshots of intermediates in the process have been created from cryo-EM data, however, many aspects of...
Topics
- Animals
- Caenorhabditis elegans
- Introns
- Mutation
- RNA Precursors
- RNA Splice Sites
- RNA Splicing
- Spliceosomes