Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Congenic mice provide in vivo evidence for a genetic locus that modulates intrinsic transforming growth factor β1-mediated signaling and bone acquisition.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jun 2012

Mukherjee Aditi, Larson Emily A, Carlos Amy S, Belknap John K, Rotwein Peter, Klein Robert F

Abstract excerpt

Osteoporosis, the most common skeletal disorder, is characterized by low bone mineral density (BMD) and an increased risk of fragility fractures. BMD is the best clinical predictor of future osteoporotic fracture risk, but is a complex trait controlled by multiple environmental and genetic determinants with individually modest effects. Quantitative trait locus (QTL) mapping is a powerful method for identifying...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow Cells
Share to Bone Morphogenetic Protein 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Laboratories

Share to Mice, Congenic

Share to Osteogenesis

Share to Stromal Cells

Share to Transforming Growth Factor beta1

Source

Open in PubMed Open full text

Identifiers

PMID: 22407846
DOI: 10.1002/jbmr.1590
PMCID: PMC4729561

Genes

LTBP4
MSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Congenic mice provide in vivo evidence for a genetic locus that modulates intrinsic transforming growth factor β1-mediated signaling and bone acquisition.PMID 22407846Read ↗

Phenotypic characterization of mice bred for high and low peak bone mass.Semantic proximity Read ↗

Collaborative cross mice in a genetic association study reveal new candidate genes for bone microarchitecture.Semantic proximity Read ↗

PPARG by dietary fat interaction influences bone mass in mice and humans.Semantic proximity Read ↗

Congenic strains of mice for verification and genetic decomposition of quantitative trait loci for femoral bone mineral density.Semantic proximity Read ↗

Genetic dissection of mouse distal chromosome 1 reveals three linked BMD QTLs with sex-dependent regulation of bone phenotypes.Semantic proximity Read ↗

Multiple quantitative trait loci for cortical and trabecular bone regulation map to mid-distal mouse chromosome 4 that shares linkage homology to human chromosome 1p36.Semantic proximity Read ↗

TIEG-null mice display an osteopenic gender-specific phenotype.Semantic proximity Read ↗

Congenic mice provide in vivo evidence for a genetic locus that modulates serum insulin-like growth factor-I and bone acquisition.Semantic proximity Read ↗

Trps1 differentially modulates the bone mineral density between male and female mice and its polymorphism associates with BMD differently between women and men.Semantic proximity Read ↗

Confirmation and fine mapping of chromosomal regions influencing peak bone mass in mice.Semantic proximity Read ↗

Identification of gender-specific candidate genes that influence bone microarchitecture in chromosome 1.Semantic proximity Read ↗

The high-bone-mass phenotype of novel transgenic mice with LRP5 A241T mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.