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Article

Multiple quantitative trait loci for cortical and trabecular bone regulation map to mid-distal mouse chromosome 4 that shares linkage homology to human chromosome 1p36.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jan 2012

Beamer Wesley G, Shultz Kathryn L, Coombs Harold F, Horton Lindsay G, Donahue Leah Rae, Rosen Clifford J

Abstract excerpt

The mid-distal region of mouse chromosome 4 (Chr 4) is homologous with human Chr 1p36. Previously, we reported that mouse Chr 4 carries a quantitative trait locus (QTL) with strong regulatory effect on volumetric bone mineral density (vBMD). The intent of this study is to utilize nested congenic strains to decompose the genetic complexity of this gene-rich region. Adult females and males from 18 nested congenic...

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Share to Chromosomes, Human, Pair 1
Share to Chromosomes, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Linkage

Share to Mice, Congenic

Share to Mice, Inbred C57BL

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Source

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Identifiers

PMID: 22031020
DOI: 10.1002/jbmr.515
PMCID: PMC3460065

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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