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Article

Congenic mice provide in vivo evidence for a genetic locus that modulates serum insulin-like growth factor-I and bone acquisition.

Endocrinology - 1 Aug 2006

Delahunty K M, Shultz K L, Gronowicz G A, Koczon-Jaremko B, Adamo M L, Horton L G, Lorenzo J, Donahue L R, Ackert-Bicknell C, Kream B E, Beamer W G, Rosen C J

Abstract excerpt

We identified quantitative trait loci (QTL) that determined the genetic variance in serum IGF-I through genome-wide scanning of mice derived from C57BL/6J(B6) x C3H/HeJ(C3H) intercrosses. One QTL (Igf1s2), on mouse chromosome 10 (Chr10), produces a 15% increase in serum IGF-I in B6C3 F2 mice carrying c3 alleles at that position. We constructed a congenic mouse, B6.C3H-10 (10T), by backcrossing c3 alleles from...

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Body Composition
Bone Remodeling
Chromosomes, Mammalian
Femur
Insulin-Like Growth Factor I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C3H

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PMID: 16675518
DOI: 10.1210/en.2006-0277

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